Front-page articles summarized hourly.
Fungal infections, especially drug-resistant strains like Candida auris, pose growing global health threats. Challenges include delayed diagnosis, limited treatment options, and resistance driven by agricultural fungicide use. Innovative science, better diagnostics, new drugs, and policy actions are urgently needed to address these issues.
AI-designed proteins can neutralize snake venom toxins more efficiently and affordably than traditional antivenoms. Using computational tools like RFdiffusion, ProteinMPNN, and AlphaFold2, researchers created stable, high-affinity binders targeting neurotoxins and cytotoxins. In vitro and in vivo tests showed effective toxin neutralization and protection in mice, with advantages including scalability, stability in low-resource settings, and ability to target multiple toxins. This approach offers a promising, cost-effective alternative to conventional treatment, addressing urgent global health needs.
Could not summarize article.
A pattern for building maintainable, performant JavaScript views without frameworks, emphasizing direct, imperative code. It uses no dependencies, ensures browser compatibility, and simplifies debugging by structuring code into sections: DOM variables, DOM views, state variables, update functions, and logic. Inspired by low-level approaches, it favors direct DOM manipulation over abstractions and frameworks, enabling portable, efficient views suitable for full applications or components.
Iron fertilization is a climate change mitigation technique that involves adding iron to the ocean surface to stimulate phytoplankton blooms, which absorb COâ‚‚. Naturally occurring dust storms and volcanic ash cause similar blooms, sequestering carbon. While experiments show promise, uncertainties remain about carbon sinking and ecosystem impacts. Research continues to develop safe, effective methods, but immediate fossil fuel reductions remain essential.
Could not summarize article.
OpenAI's new reasoning models o3 and o4-mini hallucinate more than older models, with higher rates of fabricated claims and errors, especially in knowledge and code tasks. The reason for increased hallucinations is unclear; efforts are ongoing to improve accuracy, and web search capabilities may help reduce falsehoods. Hallucinations pose challenges for commercial and safety-critical applications.
StarterPilot is an AI-powered toolkit that helps entrepreneurs validate ideas, generate names and logos, and build landing pages in minutes, enabling faster startup launches with automated branding and market insights.
Could not summarize article.
EdgeBit developed a one-shot AI agent framework for automated code maintenance, focusing on dependency updates and security fixes. The approach emphasizes focused tools, hard/soft failure handling, and persistence control to ensure accurate, safe, and autonomous updates without human intervention. Tested across various codebases, the method achieved high consistency and correctness, outperforming less focused AI models. This enables faster, reliable automation of dependency management, vulnerability patching, and code updates, reducing manual effort and increasing security responsiveness.
The article traces the history of UNIX text editors, from early line editors like ed, to visual editors like Coulouris' em, and then to vi, developed by Bill Joy at UC Berkeley. Vi's popularity led to numerous clones, including Elvis and Stevie. Bram Moolenaar's Vim, inspired by Stevie, became the most widely used vi clone, adding features and active development. Vim's evolution reflects the importance of open-source tools in computing history, with Moolenaar's contributions extending beyond software.
Made by Johno Whitaker using FastHTML