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Microbubbles in Medicine

Microbubbles are gas-filled, shell-coated bubbles that carry drugs and burst under focused ultrasound to release them at a target site. Their size keeps them in blood, but cavitation temporarily opens barriers like the blood–brain barrier, enabling brain or tumor therapies. Originating as ultrasound contrast agents, they've been engineered with heavier gases and, in some cases, magnetic steering. Potential uses include targeted chemotherapy, opening the blood–brain barrier for brain cancer, aiding stroke clot dissolution, and even breaking kidney stones or delivering mRNA. Therapeutic use remains experimental; imaging bubbles are established.

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How much? The hidden costs of restaurant dishes

Two London dishes reveal hidden costs behind restaurant prices. Apricity's asparagus starter is £21; ingredients total about £3, but labour and overhead push cost to £19.35, leaving £1.65 profit. Teal's beef dish is £36 with total cost £35.56 and a £0.44 profit. Breakdown shows Apricity: ingredients £2.18, VAT £3.67, staff £8.56, rent/utilities £2.41, running costs £2.53. Teal: ingredients £10, VAT £7.20, staff £9.60, rent/utilities £5.76, running costs £3. Hidden costs include chimney cleaning ~£4k/year, fire-safety ~£8k, outdoor licensing ~£700/year; beef and energy costs rising. Profits are squeezed; prices mislead customers.

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My Steam Machine Is a 50ft HDMI Cable

Matthew Brunelle tests a couch-gaming setup built around Valve's Steam Machine idea: a 50ft fiber-optic HDMI cable, a Steam Controller 2, and a second Bazzite NVMe drive running Linux/SteamOS. The long HDMI eliminates fiddly desktop-to-TV booting, letting him boot straight into Steam with the TV as display and HDMI audio. He prefers this over streaming and keeps control locally, though HDMI 2.1 on AMD/Linux is messy. He notes the Steam Machine is priced similarly to a self-built PC, and envisions future tweaks like swap/hibernate to switch between NixOS and desktop. In short: long HDMI cable = low-friction couch gaming.

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SOCKMAP - TCP splicing of the future

SOCKMAP is a Linux eBPF-based mechanism that offloads TCP splicing to the kernel via a SOCKMAP with two attached eBPF programs. It lets a map of TCP sockets redirect traffic without copying to userspace, potentially enabling multi-socket piping and framing via strparser (and with kTLS). The article reviews traditional methods (read/write, splice, io_submit) and benchmarks four echo servers; SOCKMAP is currently the slowest with high jitter and a bug, so not ready for prime time, but remains promising as an async, kernel-only, zero-copy solution.

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Why current LLM costs are not sustainable

AI costs are rising with frontier models like GPT-5.5, but multiple dynamics will lower prices: plateauing gains and data limits; open-weight models (e.g., GLM-5.2) offering far cheaper inference; chip and architecture advances reducing compute costs; zero switching costs and gateways enabling easy model swaps; and the rise of local models that can run on consumer hardware, cutting cloud reliance for many tasks. Expect intense price competition and cheaper, available options within 4–5 years, benefiting consumers.

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22-year-old Mozart's handwritten notebook unearthed in 'major discovery'

France’s National Library in Paris has authenticated a 248-year-old Mozart manuscript as his 1778 notebook, the 44-page book he kept while teaching harp in Paris to Marie-Louise-Philippine de Bonnieres de Guines. It contains Mozart’s daily exercises and seven flute-and-harp pieces, likely for the duke and his daughter to perform. Discovered by curator Francois-Pierre Goy among documents confiscated from the Duke of Guines during the French Revolution, the manuscript was authenticated in April 2026 by the Mozarteum Foundation.

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US Govt to individually approve who gets GPT 5.6

Reddit discussion centers on a Reuters report that the US government will approve GPT-5.6 access per customer, signaling a staggered, regulator-led rollout. Debates focus on two-tier access favoring incumbents, export controls, and threats to open/open-weight AI ecosystems; concerns about government overreach and US-China AI competition; mentions of enterprise-only access, OSTP oversight, and archiving/open mirrors as a response to supply-chain risks.

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Micron locks in historically high memory prices for five years

Micron has locked in historically high memory prices for five years by signing 16 strategic customer agreements that set a price floor and cap, guaranteeing robust margins even if costs rise. The deals cover 2026–2030 and involve upfront payments and committed purchase volumes, with about 40% of revenue tied to SCAs. Micron cites ongoing supply shortages and limited visibility of demand catching up. Q3 revenue $41.5B, DRAM $31.3B, NAND $9.9B, net income $28.9B, gross margin 84.9%. Guidance: Q4 revenue $50B, margins near 86%. Stock rose ~15% after hours.

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Why are we so obsessed with lawns?

Why are we obsessed with lawns? The piece traces the lawn’s rise from 18th‑century English landscape ideal to a global symbol of prosperity. Lawns unite practical hardscape with soft landscape, embodying British identity and, via the empire, the American Dream. A cylinder mower in the 1830s democratized lawn ownership and made mowing a status symbol. The lawn spread worldwide through parks and sports, then drew critique for heavy water and chemical use. Today it remains a powerful but contested symbol, even as some historic lawns, like Chatsworth’s Salisburys, persist as nature-friendly exceptions.

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We All Depend on Open Source. We Will Defend It Together

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Honesty gets Emacs patch rejected

An Emacs performance researcher on macOS describes months of instrumentation and patch attempts targeting rendering, memory thrashing, and regexp processing. Using GLM 5.2 (an open-weights LLM), they analyzed issues, drafted a 92-line patch, and submitted it to emacs-devel, taking full personal responsibility. GNU's policy against LLM-assisted submissions led to rejection, despite transparency about the tool and contribution. The author criticizes the policy, decides not to continue patching Emacs, noting ~40 performance patches on their drive and choosing to work on more open projects instead.

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Doing a masters while working in Spain

Jan Herlyn details earning a Master of Innovation and Research (advanced computing) in Granada, Spain, while working part-time at Adevinta. After moving from Paris, he found the program theory-heavy but practical through take-home tasks and papers; professors were supportive. It took 2.5 years, with a workplace-based thesis; the workload was intense but manageable, including cycling commutes and long study days. Social life thrived, especially with Spanish peers; Erasmus students often prioritized socializing. Tuition was about €800/semester, higher than Munich. He found it worthwhile for the subjects and friendships, though uncertain about career impact.

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What happened after 2k people tried to hack my AI assistant

Fernando Irarrázaval built hackmyclaw.com to test if his OpenClaw assistant, Fiu, would leak secrets.env when bombarded by emails. Over 2,000 people sent 6,000+ emails trying prompt-injection and impersonation; Fiu was supposed not to reply but could. Despite attacks in multiple languages, no secrets were leaked. Gmail suspended Fiu temporarily; API costs exceeded $500; a memory cue noted the activity as a security exercise. Processing batches caused creeping suspicion; each email later processed in a fresh context. The experiment used Claude Opus 4.6 and showed prompt-injection is real but not easily exploitable. He’d test weaker models and enable replies for data.

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No-One Escapes the Permanent Underclass

Argues that if AI automates all work, humanity slides into a permanent underclass surrounded by a tiny overclass whose wealth rests on AI-driven production. AIs run the economy and govern, the state enforces property rights, while humans become disempowered, with little social mobility or meaningful roles. The middle class fades; even wealth or equity won’t protect you, since in war or crisis the state may expropriate. Alignment issues aside, the piece concludes that humans risk becoming mere pets in a machine-run order.

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Libre Barcode Project

Libre Barcode Project offers fonts to create Code 39, Code 128, and EAN/UPC barcodes (with optional text below). The Code 128 Encoder has a stable URL and is included on its page. Users can input text to generate a scannable barcode using the Libre Barcode 128 Text font and copy the encoded text for use with the fonts. Support is via the issue tracker, and fonts are downloadable from the releases page or Google Fonts.

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Eyewitness at the Triangle (1911)

The Triangle Waist Factory fire in NYC on March 25, 1911 killed 146 people in 18 minutes. This Cornell ILR School Kheel Center collection provides original sources and educational materials: the fire's narrative, primary documents, survivor and witness interviews, photographs, a timeline, a floor-model of the ninth floor, bibliographic resources, guidance for students, and information on commemorating victims and the fire’s reforms; © 2018 Cornell University ILR School Kheel Center.

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AI children's books, body horror edition

lcamtuf critiques AI-generated children’s books, arguing most are indistinguishable and that letting an LLM be your voice harms authenticity. He buys a top-selling AI encyclopedia-style book to inspect real-world impact, noting cover-driven gifts and the ability to bypass traditional publishing and IP concerns. He observes frontier models may soon rival advanced intellect, but current output already includes unsettling body-horror imagery from a prominent Amazon bestseller. While tomorrow’s AI could produce flawless encyclopedias, for now the author suggests we’re “messing up some kids” until better models arrive.

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Experiments in Sports Seismology for the World Cup

Pacific Northwest Seismic Network (PNSN) will stream real-time seismic data from Seattle Stadium during World Cup matches, with footage from Football Case Study explaining seismology. Six sensors were installed inside the stadium plus a seventh, supplementing the permanent KDK station nearby; locations include ground-floor tunnel, four corners of the 300 level, and top of Hawks Nest. This builds on past deployments at Seahawks playoff games (2014–2017) and Mariners' 2025 ALDS, and follows the Beastquake 2011. The project aims to illustrate how ground motions are recorded and to engage the public via live data and social media.

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A data race that doesn't compile

Corentin Corgié shows how Rust can reject a parallel Redux-like reducer pipeline that races on shared state. He abandons a negative disjointness check in favor of a positive bijection: each slice has exactly one matching reducer. Using an HList and frunk's Sculptor, he implements a compile-time lookup that, from user-declared slices and reducers, enforces unique matches and errors on duplicates or missing mappings. The approach yields race-free parallelism and speedups; a minimal version lives in ruxe. The work highlights Rust’s type system and broader applicability of type-level patterns.

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Framework's 10G Ethernet module exposes USB-C's complexity

Geerling tests WisdPi’s 10G Ethernet Expansion Card for Framework laptops. USB-C bandwidth limits mean RTL8159 needs USB 3.2 Gen 2x2 to reach 10 Gbps; real-world speeds vary: Framework 13 (Windows) ~9.4 Gbps; Linux often lower and drivers can fail. Framework 12 shows 20 Gbps in lsusb but iperf3 ~7 Gbps. The card runs hot (~70°C), making on-lap use uncomfortable, though IEC‑compliant. Recommendation: the standard 2.5 Gbps Expansion Card (~$40) suffices for most; only buy the $99 10G Card if you need higher speeds and can tolerate heat. Card provided by WisdPi; currently out of stock.

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